disease treatment has yet to be achieved. As part of this effort, this PhD project has investigated two different NP design strategies for drug delivery: 1) the use of a magnetic field (MF) and a CPP to increase the delivery of iron oxide magnetic NPs (mNPs) to cells grown in tissueequivalent. Being magnetic they can be used as contrast agents in magnetic resonance imaging MRI. Repository Staff Only: item control page. For this reason many research groups specialized in biotechnology started to invest people and resources in this new scientic possibility. Trying to eliminate unnecessary things and focusing on main purpose of this work, in this thesis I want to illustrate just the long l rouge that connects the idea of producing a nanoparticle that can cure tumor to the point of verify its eectiveness. Dalbosco, Luca (2012 synthesis, Characterization and Functionalization of Iron Oxide Magnetic Nanoparticles for Diagnostics and Therapy of Tumors.
Development and evaluation of nanoparticles for cancer treatment
Entrapping some drugs in one of their multilayers, MNP can be used as inert carriers for drug delivery: due to their small size they can enter biological tissues, cross the dan pinchbeck thesis plasma membrane of cells and release the drug only on predetermined targets. Preview, pDF - Doctoral Thesis 35Mb, in the last decade nanotechnologies have greatly developed in many research elds such as engineering, electronic, biological and many others. It is essential for new designs to be extensively tested for toxicity and efficiency in human cells before they can be successfully released into the clinic. PhD thesis, University of Trento. The purpose of this challenge is the design, development and production of magnetic nanoparticles to use them in diagnostics and therapy of cancer disease. And nanotechonology research is just at the beginning. They can oer several possibilities to design tools, to create new techniques or improve the already existing ones, to discover innovative applications. Child, Hannah (2012 nanoparticles for biomedical applications. Developed together with many prestigious institutes all over the world, this project aims to exploit the nanotechnology possibilities in biological research. In the second investigation, AuNPs were assessed in a range of different cell types (grown in 2D) for their performance in 4 main areas; cellular toxicity, cellular uptake, c-myc knockdown and effect on the cell cycle. In the first investigation, a MF and the CPP penetratin were found to increase mNP delivery to cells grown. In both examples, the treatment of these genetic diseases lies in the delivery of synthetic nucleic acids into diseased cells, the former being called gene replacement therapy (Dobson, 2006a and the latter being called RNA interference (RNAi) therapy (Whitehead., 2009).
Synthesis, characterisation and application
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